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Composition
Each tablet contains: 4mg Chlorpheniramine maelate B.P

Each 5ml (teaspoonful) syrup contains: 2mg/5ml Chlorpheniramine maelate B.P
 

Description

Piriton is a potent antihistamine (Chlorpheniramine maleate BP) presented as tablet and syrup.

 

Pharmacology

Chlorpheniramine competes with histamine for H1-receptor sites on effector cells in the GIT, blood vessels, and respiratory tract. Pharmacokinetics - Absorption: Complete absorption. Peak blood levels are achieved in 1-2 hours. Metabolism/Excretion: The drug is metabolised in the liver. Chlorpheniramine metabolites and parent drug are excreted in the urine, 35% of total within 48 hours. Small amounts may be excreted in breastmilk. Plasma half-life: 20-24 hours Protein binding: 70%

 

Indications

Symptomatic relief of allergy, allergic rhinitis (hay fever) and conjunctivitis, urticaria, insect stings and pruritis of allergic origin; adjunct in the emergency treatment of anaphylactic shock and severe angioedema.

 

Dosage and Administration

Adult: 4mg every 4-6 hours (maximum 24mg daily) Children: Under 1 year: not recommended 1-2 years: 1mg twice daily 2-5 years: 1 mg every 4-6 hours (maximum 6mg daily), 6-12 years: 2 mg every 4-6 hours (maximum 12 mg daily).

 

Contraindications:

Prostatic enlargement, urinary retention, ileus or pyloroduodenal obstruction, glaucoma and child under 1 year.

 

Warning and Precautions:

Pregnancy and breastfeeding; renal and hepatic impairment; epilepsy

 

Side Effects

Drowsiness (rarely paradoxical stimulation with high doses, or in children or elderly), hypertension, headache, palpitations, psychomotor impairment, urinary retention, dry mouth, blurred vision, gastrointestinal disturbances; liver dysfunction; blood disorder; also rash and photosensitivity reactions, sweating and tremor, hypersensitivity reactions (including bronchospasm, angioedema and anaphylaxis).

 

Presentation

Piriton is available in both tablet and syrup.

Tablet of 250s

Syrup of 60ml .
 

PIRITON EXPECTORANT LINCTUS

Composition
Each 5ml contains:
 
  Adult Children
Chlorpheniramine maleate 2mg 1mg
Ammonium chloride 100mg 50mg
Sodium citrate 44mg 22mg


Description
Piriton expectorant linctus is a cough mixture.

Indications
Piriton expectorant linctus is an effective expectorant for use in upper respiratory tract infections including the common cold and bronchitis.

Dosage and Administration
Children 6 12 years: One teaspoonful (5ml) three to four times daily.

Adults 12 years and above: One to two teaspoonfuls (5 10ml) three to four times daily or as directed by your physician.
 

Contraindications
Hypersensitivity to antihistamines and those that have had MAOI therapy within the previous 14 days.

Warning and Precautions
Chlorpheniramine may have an additive effect when used concurrently with hypnotics and anxiolytics causing potentiation of drowsiness. A similar additive effect will result from concurrent usage of alcohol with Chlorpheniramine. Monoamine oxidase inhibitor therapy intensifies the anticholinergic effects of Chlorpheniramine. Chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin toxicity.

Side Effects
Drowsiness (rarely paradoxical stimulation with high doses, or in children or elderly), hypertension, headache, palpitations, psychomotor impairment, urinary retention, dry mouth, blurred vision, gastrointestinal disturbances; liver dysfunction; blood disorder; also rash and photosensitivity reactions, sweating and tremor, hypersensitivity reactions (including bronchospasm, angioedema and anaphylaxis).

Presentation
Piriton expectorant linctus is available in bottles of 100ml.

 

 
     
     

Evans Medical Plc

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