Composition
Each tablet contains: Paracetamol BP - 500mg

Each 5ml (teaspoonful) of syrup and suspension contains Paracetamol BP 125mg
 

Description

Evans paracetamol comes in syrup, suspensions and tablets. The syrup and suspensions are in bottles of 60ml while the tablet comes in a blister pack of 12’s and jar of 1000’s.

Pharmacology

Paracetamol has analgesic properties; it acts on the CNS to produce analgesia. It also has antipyretic properties; it inhibits the actions of endogenous pyrogen on the hypothalamic heat regulating centres thereby leading to dissipation of body heat. Pharmacokinetics: Absorption of paracetamol is rapid and almost completely absorbed from the gastrointestinal tract. Peak plasma levels are achieved within 0.5 to 2 hours. Metabolism/Excretion: Paracetamol is extensively metabolised and excreted in the urine primarily as inactive glucuronate and sulphate conjugates (94%). Approximately 4% is metabolised via cytochrome P-450 oxidase to a toxic metabolite, which is detoxified by preferential conjugation with hepatic glutathione and excreted in the urine as conjugates of cysteine and mercapturic acid. When paracetamol is used chronically or taken in large doses, glutathione stores are depleted and hepatic necrosis occurs; 2% to 4% is excreted unchanged. Elimination half-life: 1 to 3 hours. Protein binding: varies from 20% to 50% at toxic serum concentration.

Indications

Analgesic and antipyretic actions. It is indicated for the treatment of mild to moderate pains, headache, toothache, earache, neuralgia and feverish conditions.

Dosage and Administration

Syrup/Suspension: Children under 1 year: ½ - 1 teaspoonful

1 – 5 years: 1 –2 teaspoonful(s)

6 – 12 years: 2 – 4 teaspoonfuls

Tablet: Children 6 – 12 years: ½ - 1 tablet 3 or 4 times daily

Adult: Two tablets 3 to 4 times daily.

Contraindications

Hypersensitivity to paracetamol

Warning and Precautions

Paracetamol should be administered with care to patients with impaired kidney or liver function. Prolonged use of paracetamol is not advisable.

Side Effects

Haematological reactions (though usually mild) have been reported. Skin rashes and other allergic reactions occur occasionally.
 

Presentation

Syrup: Packs of 60ml and 2L Suspension:

Packs of 60ml Tablets:

Packs of 96’s and 1000’s